The flower heads are chewed to relieve the toothache and other mouth related troubles. Leaves are used externally in treatment of skin diseases. Root decoction is used as purgative. Leaf decoction is used as diuretic and lithotriptic. Whole plant is used in treatment of dysentery.The bronze-green leaves and the more potent
yellow  cone shaped flowers have a taste and properties similar to coneflower (Echinacea purpurea).
It stimulates the flow of salvia which cleanses the mouth, tones the gums, and enhances
immune function. Spilanthes also improves digestion, eases flatulence, improves the appetite, and helps to overcome nausea and vomiting by its stimulating effect on the salivary glands.

It is called the toothache plant because when you chew on the leaves or flowers it produces a numbing effect to the tongue and gums.